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Recommended dosing and dilution in adult cervical dystonia

Choose the appropriate dose in Dysport Units

  • Units of biological activity of Dysport cannot be compared to, or converted into, units of any other botulinum toxin products
  • In adult cervical dystonia, doses up to Dysport 1,000 Units (divided among affected muscles) injected intramuscularly were systematically evaluated1
    • The recommended initial dose is Dysport 500 Units given intramuscularly as a divided dose among affected muscles
    • Titrate in 250-Unit steps according to patient’s response
  • Select dose based on muscles affected, severity of muscle spasticity, prior response, and adverse reaction history following treatment with Dysport1
  • No more than 1 mL should generally be administered at any single injection site1
  • Retreatment should occur no sooner than 12 weeks after the previous injection

In CD – Common postures and muscles typically affected include*1,2:

Cervical dystonia affected postures and muscles chart
Not actual patients.
Median dose: Dysport 125 Units. Dosing considerations for the sternocleidomastoid (SCM): Limiting the dose injected unilaterally into the SCM to Dysport 150 Units or less may reduce the occurrence of dysphagia.

A simplified dilution approach1

For adult cervical dystonia

  • For other dilution options, refer to Table 1: Dilution Instructions for Dysport Vials (500 and 300 Units) in package insert Section 2.1: Instructions for Safe Use
Diluent per
Dysport 500-Unit Vial
Units per 0.1 mL
1.0 mL Dysport 50 Units
2.0 mL Dysport 25 Units
2.5 mL Dysport 20 Units
  • Using an appropriately sized sterile syringe, needle, and aseptic technique, draw up an appropriate amount of sterile, preservative-free 0.9% Sodium Chloride Injection USP for the 500-Unit vial. See table above.

For 500-Unit vials, Ipsen recommends 1.0 mL volume (50 Units per 0.1 mL).

Dysport potency units are not interchangeable with other botulinum toxin products.

Dysport® (abobotulinumtoxinA) dosing and dilution key points to keep in mind

3Asset 1 points to keep in mind with Dysport®1

  1. Vacuum. When reconstituting Dysport®, insert the needle into the vial and allow the dilutent to be pulled into the vial by partial vacuum. Do not use the vial if no vacuum is observed.
  2. Swirl. Swirl Dysport® gently into the vial to dissolve, rather than shaking or rolling.
  3. Vent. When using more than 2mL of dilutent, vent the vial to release the pressure if entering the vial again to withdraw the diluted Dysport®

Reconstituted Dysport should be a clear, colorless solution, free of particulate matter; otherwise, it should not be injected. To inject, remove the needle used to reconstitute Dysport and attach an appropriately sized new sterile needle to administer the injection. Inject into target muscle(s) within 24 hours of reconstitution. Dysport should be used for only one injection session and for only one patient after reconstitution. Once reconstituted, Dysport should be stored in the original container, in a refrigerator at 2°C to 8°C (36°F to 46°F), protected from light for up to 24 hours. It must be discarded if not used within 24 hours. Do not freeze reconstituted Dysport. Discard the vial and needle in accordance with local regulations.

Additional Resources

Dosing & Dilution Guide (Adult with Spasticity or Cervical Dystonia)

A Treatment Guide for Adult Cervical Dystonia

This illustration explains eight different muscles for administering Dysport (abobotulinumtoxinA) injection for patients with upper limb spasticity

Copay Brochure

Copay Brochure

Copay Assistance Program Flash Card

Copay Brochure

Adult Cervical Dystonia Injection Tracker

Dysport Patient Brochure

Dilution Poster

Dysport Patient Brochure

The C.L.I.M.B.® program includes comprehensive Dysport injection training:

  • Opportunity to be added to the Dysport Doctor Locator, where patients can easily find your practice if you are eligible*
  • 1:1 in-office training
  • Live group training or web conference (dosing, reconstitution, and injection simulator)
  • Educational videos, brochures, and information on purchasing and reimbursement
    *See eligibility criteria at www.CLIMB-training.com.
Media time to retreatment of cervical dystonia patients was 14 weeks with Dysport® (abobotulinumtoxinA)

Important Safety Information

Warning: Distant Spread of Toxin Effect

Postmarketing reports indicate that the effects of Dysport® (abobotulinumtoxinA) and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These may include asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including upper limb spasticity in children, and in approved indications, cases of spread of effect have been reported at doses comparable to or lower than the maximum recommended total dose.


Dysport is contraindicated in patients with known hypersensitivity to any botulinum toxin preparation or to any of the components; or in the presence of infection at the proposed injection site(s); or in patients known to be allergic to cow's milk protein. Hypersensitivity reactions including anaphylaxis have been reported.

Warnings and Precautions

Lack of Interchangeability Between Botulinum Toxin Products

The potency Units of Dysport are specific to the preparation and assay method utilized. They are not interchangeable with other preparations of botulinum toxin products, and, therefore, units of biological activity of Dysport cannot be compared to or converted into units of any other botulinum toxin products assessed with any other specific assay method.

Dysphagia and Breathing Difficulties

Treatment with Dysport and other botulinum toxin products can result in swallowing or breathing difficulties. Patients with pre-existing swallowing or breathing difficulties may be more susceptible to these complications. In most cases, this is a consequence of weakening of muscles in the area of injection that are involved in breathing or swallowing. When distant side effects occur, additional respiratory muscles may be involved. Deaths as a complication of severe dysphagia have been reported after treatment with botulinum toxin. Dysphagia may persist for several weeks, and require use of a feeding tube to maintain adequate nutrition and hydration. Aspiration may result from severe dysphagia and is a particular risk when treating patients in whom swallowing or respiratory function is already compromised. Patients treated with botulinum toxin may require immediate medical attention should they develop problems with swallowing, speech, or respiratory disorders. These reactions can occur within hours to weeks after injection with botulinum toxin.

Pre-existing Neuromuscular Disorders

Individuals with peripheral motor neuropathic diseases, amyotrophic lateral sclerosis, or neuromuscular junction disorders (e.g., myasthenia gravis or Lambert-Eaton syndrome) should be monitored particularly closely when given botulinum toxin. Patients with neuromuscular disorders may be at increased risk of clinically significant effects including severe dysphagia and respiratory compromise from typical doses of Dysport.

Human Albumin and Transmission of Viral Diseases

This product contains albumin, a derivative of human blood. Based on effective donor screening and product manufacturing processes, it carries an extremely remote risk for transmission of viral diseases and variant Creutzfeldt-Jakob disease (vCJD). There is a theoretical risk for transmission of Creutzfeldt-Jakob disease (CJD), but if that risk actually exists, the risk of transmission would also be considered extremely remote. No cases of transmission of viral diseases, CJD, or vCJD have ever been identified for licensed albumin or albumin contained in other licensed products.

Intradermal Immune Reaction

The possibility of an immune reaction when injected intradermally is unknown. The safety of Dysport for the treatment of hyperhidrosis has not been established. Dysport is approved only for intramuscular injection.

Most Common Adverse Reactions

Adults with upper limb spasticity (≥2% and greater than placebo): nasopharyngitis, urinary tract infection, muscular weakness, musculoskeletal pain, dizziness, fall, and depression.

Adults with lower limb spasticity (≥5% and greater than placebo): falls, muscular weakness, and pain in extremity.

Adults with cervical dystonia (≥5% and greater than placebo): muscular weakness, dysphagia, dry mouth, injection site discomfort, fatigue, headache, musculoskeletal pain, dysphonia, injection site pain, and eye disorders.

Pediatric patients with lower limb spasticity (≥10% and greater than placebo): upper respiratory tract infection, nasopharyngitis, influenza, pharyngitis, cough, and pyrexia.

Drug Interactions

Co-administration of Dysport and aminoglycosides or other agents interfering with neuromuscular transmission (e.g., curare-like agents), or muscle relaxants, should be observed closely because the effect of botulinum toxin may be potentiated. Use of anticholinergic drugs after administration of Dysport may potentiate systemic anticholinergic effects, such as blurred vision. The effect of administering different botulinum neurotoxins at the same time or within several months of each other is unknown. Excessive weakness may be exacerbated by another administration of botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin. Excessive weakness may also be exaggerated by administration of a muscle relaxant before or after administration of Dysport.

Use in Pregnancy

Based on animal data, Dysport may cause fetal harm. There are no adequate and well-controlled studies in pregnant women. Dysport should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Pediatric Use

Based on animal data Dysport may cause atrophy of injected and adjacent muscles; decreased bone growth, length, and mineral content; delayed sexual maturation; and decreased fertility.

Geriatric Use

In general, elderly patients should be observed to evaluate their tolerability of Dysport, due to the greater frequency of concomitant disease and other drug therapy. Subjects aged 65 years and over who were treated with Dysport for lower limb spasticity reported a greater percentage of fall and asthenia as compared to those younger (10% vs. 6% and 4% vs. 2%, respectively).

To report SUSPECTED ADVERSE REACTIONS or product complaints, contact Ipsen at 1-855-463-5127. You may also report SUSPECTED ADVERSE REACTIONS to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Dysport for injection is indicated for the treatment of:

  • Adults with cervical dystonia
  • Spasticity in adult patients
  • Lower limb spasticity in pediatric patients 2 years of age and older

Please see Full Prescribing Information including Boxed Warning and Medication Guide.

  1. Dysport® (abobotulinumtoxinA) [Prescribing Information]. Basking Ridge, NJ: Ipsen Biopharmaceuticals, Inc; September 2017.
  2. Blitzer E, Benson BE, Guss J. Botulinum Neurotoxin for Head and Neck Disorders. New York, NY. Thieme Medical Publishers, Inc. 2012.


Dysport® (abobotulinumtoxinA) for injection is indicated for the treatment of:

The safety and effectiveness of Dysport® injected into upper limb muscles or proximal muscles of the lower limb for the treatment of spasticity in pediatric patients has not been established.

Safety and effectiveness in pediatric patients with lower limb spasticity below 2 years of age have not been evaluated.

Safety and effectiveness in pediatric patients with cervical dystonia or upper limb spasticity have not been established.

Click here for Full Prescribing Information and Medication Guide

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If you practice within an institution:

Please acquire Dysport® (abobotulinumtoxinA) from your wholesalers

If in a private practice or clinic, please select the applicable coverage benefit to acquire Dysport® (abobotulinumtoxinA):

If Dysport® (abobotulinumtoxinA) is covered under the medical benefit, choose the best option for your office:

To purchase Dysport® (abobotulinumtoxinA) directly (buy and bill):

  • Requires upfront financial investment
  • Your office acquires Dysport® directly from a select group of Specialty Distributors
  • Your office collects copay/coinsurance directly from the patient
  • Your office seeks reimbursement from payer(s)

To purchase from authorized specialty distributors of record, select from the distributors below:

Besse Medical

Call 1-800-543-2111

Order online

Cardinal Specialty

Call 1-866-300-3838

Order online

CuraScript SD

Call 1-877-599-7748

Order online

McKesson Specialty Health

Call 1-855-477-9800

Order online

If Dysport® (abobotulinumtoxinA) is covered under the pharmacy benefit, IPSEN CARES® can help you find a network specialty pharmacy:

Call IPSEN CARES® at 1-866-435-5677,

Monday-Friday, from 8:00 AM to 8:00 PM ET (5:00 AM to 5:00 PM PT).

To purchase from specialty pharmacy assignment of benefit (AOB):

  • No upfront financial investment
  • IPSEN CARES® can provide helpful information on selecting the appropriate Specialty Pharmacy Provider by calling 1-866-435-5677
  • Patient pays copay/coinsurance directly to Specialty Pharmacy
  • Specialty Pharmacy ships product directly to your office

Call IPSEN CARES® at 1-866-435-5677,

Monday-Friday, from 8:00 AM to 8:00 PM ET (5:00 AM to 5:00 PM PT).